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Updated: Jul 12, 2025

Method for Measuring the Activity of Deubiquitinating Enzymes in Cell Lines and Tissue Samples
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Method for Measuring the Activity of Deubiquitinating Enzymes in Cell Lines and Tissue Samples

Published on: May 10, 2015

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Deubiquitylating Enzymes in Cancer and Immunity

Jiang Ren1, Peng Yu2, Sijia Liu3,4

  • 1The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, P. R. China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|October 27, 2023
PubMed

Insights

Deubiquitylating enzymes (DUBs) regulate cellular processes by removing ubiquitin. Their dysregulation is linked to cancer and immune disorders, highlighting their complex roles.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Deubiquitylating enzymes (DUBs) are crucial for maintaining cellular homeostasis by removing ubiquitin.
  • DUBs exhibit specificity in cleaving ubiquitin chains and can function independently of their catalytic activity.
  • Dysregulation of DUBs contributes to diseases, particularly cancer and immune disorders.

Purpose of the Study:

  • To review the dual roles of DUBs in cancer development and progression.
  • To summarize the involvement of DUBs in various immune system functions and disorders.
  • To discuss the potential and challenges of developing DUB inhibitors for clinical applications.

Main Methods:

  • Literature review of DUBs' functions in cancer.
  • Analysis of DUBs' roles in innate and adaptive immunity.
  • Examination of clinical development prospects for DUB inhibitors.

Main Results:

  • DUBs play Janus-faced roles in cancer, influencing proteasomal degradation, DNA repair, apoptosis, and metastasis.
  • DUBs are implicated in innate immune receptor signaling, inflammation, and autoimmune diseases.
  • The clinical development of DUB inhibitors presents both opportunities and challenges.

Conclusions:

  • DUBs are critical regulators with multifaceted roles in cancer and immunity.
  • Understanding DUBs' complex functions is essential for developing targeted therapies.
  • Further research into DUB inhibitors holds promise for treating cancer and immune-related diseases.
Keywords:
cancerdeubiquitylating enzymes (DUBs)immunitytherapeutic approach

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