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Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
Published on: May 2, 2018
Plasmid-encoded VCC-1 β-lactamase in a clinical isolate of Aeromonas caviae
Darya Bychenko Banyas1, Mor Lurie-Weinberger1, Reut Efrati Epchtien1
1National Institute for Antibiotic Resistance and Infection Control, Israel Ministry of Health , , Israel.
Abstract:
carbapenemase (VCC-1) is a chromosomal encoded class A carbapenemase thus far reported in environmental Vibrio cholerae isolates. Here, we report the first isolation of a bla -carrying Aeromonas caviae from a clinical sample in Israel. The isolate was resistant to all β-lactam agents, including carbapenems. The bla was located on a large plasmid. GC content suggests that the origin of the bla gene is neither Aeromonas nor Vibrio spp. but an unknown progenitor.
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