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Related Experiment Video

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Double-Layer Hydrogel with Glucose-Activated Two-Stage ROS Regulating Properties for Programmed Diabetic Wound

Min Tan1,2, Jing Zeng1,2, Fu-Zhong Zhang1,2

  • 1Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.

ACS Applied Materials & Interfaces
|October 27, 2023
PubMed
Summary
This summary is machine-generated.

This study developed a novel double-layer hydrogel to manage reactive oxygen species (ROS) for improved diabetic wound healing. The hydrogel offers two-stage ROS regulation, showing potential as a future diabetic wound dressing.

Keywords:
diabetic wound healingdouble-layer hydrogelreactive oxygen species

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing

Background:

  • Diabetic wound healing is a significant clinical challenge due to impaired healing processes.
  • Uncontrolled reactive oxygen species (ROS) exacerbate inflammation and impede healing in diabetic wounds.

Purpose of the Study:

  • To construct and evaluate a novel double-layer hydrogel system for programmed, two-stage regulation of ROS in diabetic wound environments.
  • To promote effective healing of diabetic wounds through targeted ROS management.

Main Methods:

  • Fabrication of a double-layer hydrogel with an inner layer containing glucose oxidase (Gox), ferrocene-modified quaternary ammonium chitosan (Fc-QCs), and poly(β-cyclodextrin) (Pβ-CD) for early-stage antibacterial ROS generation.
  • An outer layer of gelatin and dopamine designed for later-stage ROS scavenging upon contact with the wound environment.
  • In vitro and in vivo assessments including antibacterial activity, ROS scavenging capacity, and diabetic wound healing efficacy.

Main Results:

  • The inner layer effectively generated hydroxyl radicals (•OH) for antibacterial action and gradually degraded.
  • The outer layer demonstrated significant ROS scavenging capabilities in the later stages of healing.
  • The double-layer hydrogel exhibited enhanced antibacterial properties, efficient ROS modulation, and promoted accelerated diabetic wound healing.

Conclusions:

  • The developed double-layer hydrogel possesses unique two-stage ROS regulating properties, addressing the complexities of diabetic wound healing.
  • This innovative hydrogel demonstrates significant potential as an advanced wound dressing for treating challenging diabetic wounds.