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Updated: Jul 12, 2025

A Novel Technique for Generating and Observing Chemiluminescence in a Biological Setting
Published on: March 9, 2017
Molecular Engineering of Luminogens for High-Integrity Imaging of Hydrogen Polysulfides via Activatable
Zhecha Zheng1, Jinzhu Gao1, Rongchen Wang1
1Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai 200237, People's Republic of China.
Abstract:
Understanding biological events associated with H2S rather than mediated by H2S is of great significance but remains to be solved due to a lack of high-integrity imaging tools. In this study, we report a chemoselective probe for H2S over H2S through the molecular engineering of luminogens. Based on our search for H2S-activatable probes with high selectivity, we fabricate water-soluble and biocompatible nanoprobes. Such a designed nanoprobe shows rare aggregation-induced dual-color fluorescence responses to H2S, lighting up bright emissions at 588 and 750 nm, respectively. By use of this activatable dual-color fluorescence, high-integrity identification of intracellular H2S was successfully realized. Thus, our approach to H2S-activated multicolor fluorescent probes could provide valuable insight into interrogating H2S-mediated biological events.
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