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Related Experiment Videos

Is sickle cell crisis a thrombotic event?

D Green, J P Scott

    American Journal of Hematology
    |December 1, 1986
    PubMed
    Summary

    Sickle cell disease patients show chronic intravascular coagulation, but pain crises are not thrombotic events. Tests for fibrinogen, beta-thromboglobulin, fibrinopeptide A, and protein C revealed no crisis-specific changes.

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    Area of Science:

    • Hematology
    • Vascular Biology
    • Thrombosis Research

    Background:

    • Intravascular coagulation is a known complication in sickle cell disease, but its role in pain crises is debated.
    • Previous studies suggest a link between thrombosis and sickle cell disease, yet specific data on pain crisis events are limited.

    Purpose of the Study:

    • To investigate the role of intravascular coagulation during sickle cell pain crises.
    • To compare hemostasis markers in patients during and between pain crises versus healthy controls.

    Main Methods:

    • Studied 24 sickle cell patients during and between pain crises.
    • Measured fibrinogen, beta-thromboglobulin (beta-TG), fibrinopeptide A (FPA), and protein C using sensitive hemostasis tests.
    • Utilized radioimmunoassay and clotting assays for quantitation.

    Main Results:

    • Fibrinogen, beta-TG, and FPA levels were elevated, and protein C was decreased in sickle cell patients compared to healthy controls.
    • No significant changes in fibrinogen, beta-TG, FPA, or protein C were observed between pain crisis and asymptomatic states in sickle cell patients.
    • Chronic intravascular coagulation is indicated by consistently altered hemostasis markers in sickle cell patients.

    Conclusions:

    • Sickle cell disease patients exhibit chronic intravascular coagulation.
    • Pain crises in sickle cell disease are not characterized as acute thrombotic events.
    • Hemostasis markers remain altered chronically, independent of acute pain episodes.

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