Related Experiment Video
Updated: Jul 12, 2025
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.1K
Disparities With Systemic Therapies for Black Men Having Advanced Prostate Cancer: Where Do We Stand?
Jun Gong1, Daniel M Kim1, Amanda M De Hoedt2
1Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Summary
Racial disparities in prostate cancer treatment outcomes are narrowing for Black men with metastatic disease. Evidence suggests similar or better outcomes with systemic therapies when access to care is equitable.
Area of Science:
- Oncology
- Health Disparities Research
- Cancer Treatment Outcomes
Background:
- Prostate cancer disproportionately affects Black men, with documented disparities impacting survival.
- Historically, Black men with prostate cancer have faced poorer outcomes compared to White men.
- Multilevel disparities contribute significantly to these survival differences.
Purpose of the Study:
- To review trends in racial disparities for systemic therapy outcomes in Black men with metastatic prostate cancer.
- To compare outcomes between Black and White men receiving systemic therapy for advanced prostate cancer.
- To investigate the impact of equitable health care access on treatment outcomes.
Main Methods:
- Review of real-world registry data.
- Analysis of prospective clinical trials.
- Focus on studies with standardized health care delivery and follow-up.
Main Results:
- Growing evidence indicates Black men may achieve similar or superior outcomes with systemic therapies compared to White men in metastatic prostate cancer.
- Prospective studies and clinical trials corroborate these findings, particularly in settings with standardized care.
- Equitable access to health care and follow-up appears to mitigate outcome disparities.
Conclusions:
- Nonbiological factors are critical drivers of racial disparities in advanced prostate cancer.
- Addressing barriers to health care access and delivery is essential.
- Increasing participation in clinical trials is key to overcoming systemic therapy outcome disparities for Black men.
Related Concept Videos
01:20Disorders of the Male Reproductive System
431
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
431
02:56Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K