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N-glycosylation in Archaea: Unusual sugars and unique modifications
Anna Notaro1, Marianna Zaretsky2, Antonio Molinaro3
1Department of Agricultural Sciences, University of Napoli Federico II, Portici, Italy.
Abstract:
Archaea are microorganisms that comprise a distinct branch of the universal tree of life and which are best known as extremophiles, residing in a variety of environments characterized by harsh physical conditions. One seemingly universal trait of Archaea is the ability to perform N-glycosylation. At the same time, archaeal N-linked glycans present variety in terms of both composition and architecture not seen in the parallel eukaryal or bacterial processes. In this mini-review, many of the unique and unusual sugars found in archaeal N-linked glycans as identified by nuclear magnetic resonance spectroscopy are described.
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