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Updated: Jul 12, 2025

Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines
Published on: March 17, 2023
Mitochondrial control of antigen presentation in cancer cells
Ruth Soler-Agesta1, Alberto Anel2, Lorenzo Galluzzi3
1Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Apoptosis, Immunity and Cancer Group, Department of Biochemistry and Molecular and Cell Biology, University of Zaragoza/Aragón Health Research Institute, Zaragoza, Spain.
Abstract:
Cytotoxic T lymphocytes recognize and kill cancer cells when the latter present antigenic epitopes complexed with MHC class I molecules on their surface. In a recent Science paper, Mangalhara et al. show that alterations of the mitochondrial electron flow upregulate multiple factors involved in antigen presentation via a succinate-dependent epigenetic mechanism.
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