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Giardiasis and diarrhea in dogs: Does the microbiome matter?
Sharon Kuzi1, Soha Zgairy2, Barbara A Byrne3
1Hebrew University Veterinary Teaching Hospital and Koret School of Veterinary Medicine, Robert H. Smith Faculty of Agriculture, Food and Environment Hebrew University of Jerusalem, Rehovot, Israel.
Journal of Veterinary Internal Medicine
|October 27, 2023
Summary
The fecal microbiome composition of dogs with Giardia duodenalis (Gd) infection is similar, regardless of diarrhea. Giardiasis in dogs does not show significant dysbiosis, suggesting other factors influence disease severity.
Area of Science:
- Veterinary Medicine
- Microbiome Research
- Infectious Diseases
Background:
- Giardia duodenalis (Gd) is a common cause of intestinal parasitosis in dogs.
- The role of the intestinal microbiome in the clinical presentation of giardiasis is not well understood.
Purpose of the Study:
- To investigate the fecal microbiome characteristics in dogs infected with Giardia duodenalis.
- To compare microbial composition and dysbiosis index between diarrheic and non-diarrheic dogs with giardiasis.
Main Methods:
- A cross-sectional study analyzed fecal samples from kenneled dogs diagnosed with Gd via ELISA.
- Fecal microbial composition, diversity (alpha and beta), and dysbiosis index (DI) were assessed.
- Comparisons were made between diarrheic and non-diarrheic dogs, stratified by sex and age.
Main Results:
- No significant differences in overall microbial diversity or specific taxa were found between diarrheic and non-diarrheic dogs.
- Alpha diversity was higher in male diarrheic dogs compared to females.
- Abundances of Clostridium spp. were higher in male diarrheic dogs; Proteobacteria were more prevalent in diarrheic dogs, and Verrucomicrobia less prevalent in younger dogs.
Conclusions:
- The fecal microbiome composition is similar in symptomatic and asymptomatic dogs with giardiasis.
- Giardiasis in dogs is not characterized by significant dysbiosis based on the fecal DI.
- Factors beyond the fecal microbiome likely influence the clinical severity of giardiasis in dogs.
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