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Host Susceptibility to Nontuberculous Mycobacterial Pulmonary Disease

Ho Namkoong1, Steven M Holland2

  • 1Department of Infectious Diseases, Keio University School of Medicine, 35 Shinanomachi Shinjyuku-ku, Tokyo 160-8582, Japan.

Clinics in Chest Medicine
|October 27, 2023
PubMed

Insights

Nontuberculous mycobacteria (NTM) pulmonary disease susceptibility is linked to host genetics. Research identifies immune, CFTR, cilia, and connective tissue genes as key factors in NTM infection risk.

Area of Science:

  • Pulmonary Medicine
  • Infectious Diseases
  • Genetics

Background:

  • Nontuberculous mycobacteria (NTM) pulmonary disease is a chronic, progressive lung infection.
  • Host susceptibility influences NTM infection incidence, observed in specific populations and familial clusters.
  • Previous research suggests genetic predispositions to NTM infection.

Purpose of the Study:

  • To summarize current understanding of host susceptibility in NTM pulmonary disease.
  • To highlight genetic factors identified through recent genomic studies.
  • To emphasize the need for further research into NTM pathogenesis.

Main Methods:

  • Review of existing literature on Nontuberculous mycobacteria (NTM) pulmonary disease.
  • Analysis of findings from whole exome sequencing and genome-wide association studies.
  • Identification of commonly implicated host genetic pathways.

Main Results:

  • Host susceptibility to NTM infection is influenced by genetic factors.
  • Specific genes related to immune function, CFTR, cilia, connective tissue, and ion homeostasis are implicated.
  • Demographic patterns (e.g., Asian populations, slender women) and familial clustering suggest a genetic component.

Conclusions:

  • Genetic factors play a significant role in the development of Nontuberculous mycobacteria (NTM) pulmonary disease.
  • Further large-scale international collaborative studies and functional analyses are crucial.
  • Elucidating host susceptibility mechanisms will aid in understanding and managing NTM infections.
Keywords:
GWASHost susceptibilityMACNTMWES

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