Transporting Comparative Effectiveness Evidence Between Countries: Considerations for Health Technology Assessments
Alex J Turner1, Cormac Sammon1, Nick Latimer2,3
1Putnam PHMR, London, UK.
Pharmacoeconomics
|October 27, 2023
Summary
This study introduces transportability methods for health technology assessment (HTA). It addresses using real-world data from different populations to ensure evidence relevance and support HTA decisions.
Area of Science:
- Health Technology Assessment (HTA)
- Real-World Evidence (RWE)
- Comparative Effectiveness Research
Background:
- Health technology assessment agencies prioritize internal validity of comparative effectiveness evidence.
- Increasing use of external real-world data raises concerns about external validity, or transportability.
- A preference for local data has emerged due to transportability challenges.
Purpose of the Study:
- To provide an introduction to transportability in the context of health technology assessment.
- To summarize assumptions and methods for identifying and adjusting for lack of transportability.
- To discuss considerations for using transportability methods within HTA frameworks.
Main Methods:
- Review of existing methods for addressing transportability of real-world evidence.
- Discussion of guidance for identifying effect modifiers and choosing target populations.
- Exploration of how transportability evaluations can integrate into HTA submission and decision processes.
Main Results:
- Methods exist to address transportability by accounting for cross-country differences.
- Current consideration of these methods in HTA is limited due to knowledge gaps and integration uncertainties.
- Guidance is needed for effective utilization of transportability methods in HTA.
Conclusions:
- Transportability is crucial for utilizing real-world data in health technology assessment.
- Further development and integration of transportability methods are needed to enhance HTA.
- This article provides a framework for understanding and applying transportability in HTA settings.
Related Concept Videos
01:12Hazard Ratio
137
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
For example, in a clinical trial...
137
01:16Bioequivalence: Overview
1.1K
Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
1.1K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
133
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
133
01:16Clinical Trials
6.8K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
6.8K
01:28International Nursing Organizations II
1.0K
The World Health Organization (WHO) is a specialized agency of the United Nations based in Geneva. The WHO has many initiatives that center around health. Primarily, they lead global efforts to expand universal health coverage using science-based policies and programs. They are also responsible for shaping health research agendas and developing norms and standards.
The WHO provides expert team support, including funding, vaccines, testing, and treatment tools at the country level to fight...
The WHO provides expert team support, including funding, vaccines, testing, and treatment tools at the country level to fight...
1.0K
01:30Health Information Technology and Healthcare Information System
852
Health Information Technology (HIT)
Health Information Technology, commonly called HIT, integrates advanced information systems and technology in healthcare settings. Its primary functions include:
Health Information Technology, commonly called HIT, integrates advanced information systems and technology in healthcare settings. Its primary functions include:
852