Related Experiment Video
Updated: Jul 12, 2025
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
18.3K
A Descriptive Review of Medication-Overuse Headache: From Pathophysiology to the Comorbidities
Srdjan Ljubisavljevic1, Marina Ljubisavljevic1, Radomir Damjanovic1
1Department for Neurology, University Clinical Centre of Nis, 18000 Nis, Serbia.
Brain Sciences
|October 28, 2023
Summary
Medication-overuse headache (MOH) is a global issue. Limiting acute medications is crucial for prevention, though poorly controlled headaches may also contribute to increased use.
Area of Science:
- Neurology
- Pharmacology
Background:
- Medication-overuse headache (MOH) presents diagnostic challenges and global health concerns.
- Understanding MOH requires a comprehensive review of its multifaceted aspects.
Purpose of the Study:
- To review risk factors, comorbidities, pathophysiology, clinical presentation, management, and prognosis of MOH.
- To synthesize findings from over 15,000 studies conducted between 2010 and 2023.
Main Methods:
- Systematic review and integration of existing literature.
- Analysis of studies from the University Medical Library database (2010-2023).
Main Results:
- All acute migraine treatments may contribute to MOH, with varying propensities.
- Triptans and other acute painkillers might be exceptions, but awareness remains low.
- Practitioners and the public show limited awareness of medication overuse issues and consequences.
Conclusions:
- Restricting acute medication use is necessary for MOH prevention.
- Increased medication intake could reflect underlying poorly controlled headaches.
- Further research is needed for precise MOH management mechanisms and understanding its evolution.
Related Concept Videos
01:25Analgesia and Pain Management
636
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
636
01:15Drug Abuse and Addiction: Pharmacological Phenomena
489
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
489
01:24Substance Use Disorders Affecting Sleep
174
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
174
01:20Desensitization and Tachyphylaxis
1.8K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
1.8K
01:15Drug Dosage Regimen: Overview
3.6K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
3.6K
01:02Prescription, Nonprescription and Orphan Drugs
742
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
742