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A Narrative Review of the Association between Prematurity and Attention-Deficit/Hyperactivity Disorder and
Yarden S Fraiman1, Genevieve Guyol2, Dolores Acevedo-Garcia3
1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Insights
Preterm birth increases the risk of attention-deficit/hyperactivity disorder (ADHD). This review explores prematurity
Area of Science:
- Neuroscience
- Pediatrics
- Public Health
Background:
- Preterm birth is a significant risk factor for neurodevelopmental disorders.
- Attention-deficit/hyperactivity disorder (ADHD) is the most common childhood neurobehavioral disorder.
- Prematurity and ADHD impact multiple life domains in children.
Purpose of the Study:
- To review the association between prematurity and ADHD.
- To introduce the "ADHD Care Cascade" framework for service access.
- To examine racial and ethnic inequities in preterm birth and ADHD care.
Main Methods:
- Narrative review of existing literature.
- Development of the "ADHD Care Cascade" model.
- Life-course approach to analyze layered inequities.
Main Results:
- Established link between prematurity and increased ADHD risk.
- Identified disparities in healthcare access for ADHD.
- Highlighted how cumulative inequities exacerbate neurodevelopmental impacts.
Conclusions:
- Prematurity poses a substantial risk for ADHD.
- The "ADHD Care Cascade" illustrates critical points for intervention.
- Addressing racial and ethnic inequities is crucial for vulnerable children's outcomes.
Abstract:
Preterm birth is associated with an increased risk of neurodevelopmental and neurobehavioral impairments including attention-deficit/hyperactivity disorder (ADHD), the most common neurobehavioral disorder of childhood. In this narrative review, we examine the known associations between prematurity and ADHD and highlight the impact of both prematurity and ADHD on multiple domains across the pediatric life-course. We develop a framework for understanding the health services journey of individuals with ADHD to access appropriate services and treatments for ADHD, the "ADHD Care Cascade". We then discuss the many racial and ethnic inequities that affect the risk of preterm birth as well as the steps along the "ADHD Care Cascade". By using a life-course approach, we highlight the ways in which inequities are layered over time to magnify the neurodevelopmental impact of preterm birth on the most vulnerable children across the life-course.
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