Sperm antibodies in normal men: association with a history of nongonococcal urethritis (NGU)

The incidence and specificity of sperm antibodies was examined, retrospectively, in a group of 80 normal men (64 sperm donors and 16 prevasectomy patients). Seven (8.5%) were positive for sperm-bound antibodies by immunobead test (IBT), but the antibodies were restricted to the sperm tail-tip. There was a higher (p less than 0.001) incidence of nongonococcal urethritis (NGU) in the IBT-positive men, suggesting a possible causal relationship.