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Updated: Jul 12, 2025

Author Spotlight: Gut Microbiome-Lung Tissue Communication Through Short-Chain Fatty Acid Analysis
Published on: June 21, 2024
Roles of Short-Chain Fatty Acids in Inflammatory Bowel Disease
Yoonhwa Shin1,2,3, Sunhee Han1,2,3, Juhui Kwon1,2,3
1Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Abstract:
The gut microbiome is a diverse bacterial community in the human gastrointestinal tract that plays important roles in a variety of biological processes. Short-chain fatty acids (SCFA) are produced through fermentation of dietary fiber. Certain microbes in the gut are responsible for producing SCFAs such as acetate, propionate and butyrate. An imbalance in gut microbiome diversity can lead to metabolic disorders and inflammation-related diseases. Changes in SCFA levels and associated microbiota were observed in IBD, suggesting an association between SCFAs and disease. The gut microbiota and SCFAs affect reactive oxygen species (ROS) associated with IBD. Gut microbes and SCFAs are closely related to IBD, and it is important to study them further.
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