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Updated: Jul 12, 2025

A Mouse Model of Ankle-Subtalar Complex Joint Instability
Published on: October 28, 2022
Anthropomorphic Characterization of Ankle Joint
Dinesh Gundapaneni1, James T Tsatalis2, Richard T Laughlin3
1Department of Biomedical, Industrial and Human Factors Engineering, Wright State University, Dayton, OH 45435, USA.
Ankle joint morphology varies significantly between males and females, impacting total ankle replacement device design. Current implants fit only a limited population, necessitating improved, personalized designs based on anatomical data.
Area of Science:
- Orthopedics
- Biomedical Engineering
- Anatomy
Background:
- Total ankle replacement (TAR) is an alternative to arthrodesis, but long-term results are often unsatisfactory.
- Successful TAR requires precise ankle joint implant design, necessitating detailed anatomical knowledge.
Purpose of the Study:
- To quantitatively assess ankle joint morphology in relation to gender and age.
- To provide data for improving total ankle replacement device design.
Main Methods:
- Collected imaging data from 22 subjects (male/female, three age groups).
- Performed 40 morphological measurements on the tibia and talus in sagittal and coronal planes.
- Conducted statistical analyses to compare gender, age groups, and imaging techniques.
Main Results:
- Significant gender-based differences (p<0.05) were found in 13 critical ankle parameters (e.g., TiAL, TaW, TTL).
- Young adults differed significantly (p<0.05) from adults in 15 parameters (e.g., TiAL, TiW, TaAL).
- Positive correlations (r>0.70) observed between tibial and talar width, and sagittal radius values.
Conclusions:
- Current total ankle replacement device sizes are inadequate for a large portion of the population studied.
- Understanding gender and age effects on ankle morphology is crucial for designing better, personalized ankle implants.
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