Are Ischemic Stroke and Alzheimer's Disease Genetically Consecutive Pathologies?

Area of Science:

• Neuroscience
• Genomics
• RNA Biology

Background:

• Complex central nervous system diseases, including Alzheimer's disease (AD) and ischemic stroke (IS), present significant global health challenges.
• Ischemic stroke is a leading cause of disability and mortality, while Alzheimer's disease is the primary neurodegenerative disorder impacting quality of life.
• Emerging evidence indicates shared risk factors, pathogenic mechanisms, and molecular signatures between AD and IS.

Purpose of the Study:

• To review current genomics and RNA biology studies concerning ischemic stroke and Alzheimer's disease.
• To elucidate the interconnectedness of the pathologies underlying AD and IS.
• To identify potential genomic and RNA biomarkers for disease risk prediction and therapeutic development.

Main Methods:

• Comprehensive literature review of genomics studies in IS and AD.
• Analysis of RNA biology research focusing on shared molecular pathways.
• Synthesis of findings to highlight common genetic and molecular underpinnings.

Main Results:

• Identification of overlapping genomic architectures between IS and AD.
• Characterization of shared molecular signatures and RNA molecules implicated in both diseases.
• Evidence supporting common pathogenic factors contributing to neurodegeneration and cerebrovascular events.

Conclusions:

• The shared genomic and RNA biology of IS and AD suggests a common etiological basis.
• Specific genomic loci and RNA molecules represent promising targets for future diagnostic and therapeutic interventions.
• Further research into these shared mechanisms is crucial for advancing the management of these complex neurological disorders.