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Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
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SKAP2-A Molecule at the Crossroads for Integrin Signalling and Immune Cell Migration and Function

Marijn Wilmink1, Marianne Rebecca Spalinger1

  • 1Department for Gastroenterology and Hepatology, University Hospital Zürich, Sternwartstrasse 14, 8091 Zürich, Switzerland.

Biomedicines
|October 28, 2023
PubMed

Src-kinase associated protein 2 (SKAP2) is an intracellular scaffolding protein that is broadly expressed in immune cells and is involved in various downstream signalling pathways, including, but not limited to, integrin signalling. SKAP2 has a wide range of binding partners and fine-tunes the rearrangement of the cytoskeleton, thereby regulating cell migration and immune cell function. Mutations in SKAP2 have been associated with several inflammatory disorders such as Type 1 Diabetes and Crohn's disease. Rodent studies showed that SKAP2 deficient immune cells have diminished pathogen clearance due to impaired ROS production and/or phagocytosis. However, there is currently no in-depth understanding of the functioning of SKAP2. Nevertheless, this review summarises the existing knowledge with a focus of its role in signalling cascades involved in cell migration, tissue infiltration and immune cell function.

Keywords:
SKAP55-HOMSrc-kinase associated protein 2integrin signallingmacrophage function

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