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Analyzing Facial Asymmetry in Alzheimer's Dementia Using Image-Based Technology.

Ching-Fang Chien1,2, Jia-Li Sung3, Chung-Pang Wang3

  • 1Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan.

Biomedicines
|October 28, 2023
PubMed
Summary
This summary is machine-generated.

Facial asymmetry may indicate accelerated aging in Alzheimer's dementia (AD). This study found significant differences in facial asymmetry between AD patients and healthy controls, suggesting it could be a useful detection tool.

Keywords:
Alzheimer’s dementiaProcrustes methodaccelerated agingfacial asymmetryfacial landmarks

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Area of Science:

  • Neurology
  • Biomedical Engineering
  • Medical Imaging

Background:

  • Alzheimer's dementia (AD) is linked to accelerated brain aging.
  • Facial asymmetry naturally increases with age.
  • Facial imaging offers a less invasive alternative to brain imaging for AD assessment.

Purpose of the Study:

  • To investigate if Alzheimer's dementia (AD) is associated with accelerated aging patterns in facial asymmetry.
  • To develop and apply novel facial asymmetry measures for AD detection.

Main Methods:

  • Utilized a 3D camera to capture facial images from 150 AD patients and 150 controls.
  • Employed the OpenFace machine-learning algorithm to identify 68 facial landmarks.
  • Applied image registration to quantify asymmetry using landmark superimposition distances.

Main Results:

  • Found significantly different facial asymmetry in 20 out of 29 landmark pairs for AD patients compared to controls (p < 0.05).
  • AD-associated asymmetry was most prominent around the face edge, eyebrows, eyes, nostrils, and mouth.
  • Demonstrated a correlation between Alzheimer's dementia and increased facial asymmetry.

Conclusions:

  • Facial asymmetry evaluation shows potential as a non-invasive tool for Alzheimer's dementia detection.
  • The findings suggest that facial asymmetry reflects accelerated aging processes in AD.
  • Further research into facial asymmetry could enhance early AD diagnosis.