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Scalable Processing of Cyclic Olefin Copolymer (COC) Microfluidic Biochips.

Rodolfo G Rodrigues¹, Pedro G M Condelipes¹, Rafaela R Rosa¹

¹Instituto de Engenharia de Sistemas e Computadores-Microsistemas e Nanotecnologias (INESC MN), Rua Alves Redol 9, 1000-029 Lisbon, Portugal.

|October 28, 2023

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Cyclic olefin copolymer (COC) offers a promising alternative to polydimethylsiloxane (PDMS) for microfluidic devices. COC microfluidics demonstrate comparable performance and potential for mass production in biosensing applications.

Area of Science:

Materials Science
Chemical Engineering
Biotechnology

Background:

Polydimethylsiloxane (PDMS) is a common material for microfluidics but has limitations including hydrophobicity, molecule absorption, low stiffness, and scalability issues.
The need for alternative materials with improved properties and mass production capabilities is evident in microfluidic device fabrication.
Cyclic olefin copolymer (COC) presents a viable alternative due to its stiffness, lower cost, and suitability for mass production.

Purpose of the Study:

To develop and optimize a fabrication method for microfluidic devices using cyclic olefin copolymer (COC).
To evaluate the material properties of COC for microfluidic applications and compare them against polydimethylsiloxane (PDMS).
To demonstrate the potential of COC-based microfluidic devices in biosensing, specifically for DNA hybridization assays.

Keywords:

contact angles cyclic olefin copolymer (COC)hot embossing microfluidics molecular diffusion polydimethylsiloxane (PDMS)thermal bonding

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Main Methods:

Process optimization for molding, sealing, and liquid handling in COC microfluidic device fabrication.
Evaluation of COC microfluidic device properties: molecular diffusion, burst pressure, temperature resistance, and surface treatment susceptibility.
Comparative analysis of COC and PDMS microfluidic devices.
Performance testing of a COC-based microfluidic device using a DNA hybridization assay.

Main Results:

Optimized methods for COC microfluidic fabrication were established, addressing molding, sealing, and liquid handling.
COC microfluidic devices exhibited favorable properties including good temperature resistance and suitability for surface treatments.
Performance comparison indicated COC as a competitive alternative to PDMS for microfluidic applications.
Successful demonstration of a DNA hybridization assay on the COC-based microfluidic platform.

Conclusions:

Cyclic olefin copolymer (COC) is a suitable material for fabricating microfluidic devices, offering advantages over PDMS.
The developed fabrication method and material properties support the use of COC in microfluidics.
COC-based microfluidic devices show significant potential for applications in biosensing and Lab-on-a-Chip technologies.