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Updated: Jul 12, 2025
Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
Lipid Profile in Multiple Sclerosis: Functional Capacity and Therapeutic Potential of Its Regulation after
Jose Enrique de la Rubia Ortí1, Jose Luis Platero Armero1, María Cuerda-Ballester2
1Department of Nursing, Catholic University of Valencia San Vicente Mártir, 46001 Valencia, Spain.
Background:
Multiple sclerosis (MS) patients present dyslipidemia and functional disability. Epigallocatechin gallate (EGCG) and coconut oil have been shown to be effective against dyslipidemia.
Objective:
To analyze the relationship between lipid profiles, fat consumption, and functional disability in patients with MS after administering EGCG and coconut oil.
Methods:
A four-month pilot study was conducted on 45 MS patients, divided into an intervention group (IG) and a control group (CG). The IG received 800 mg of EGCG and 60 mL of coconut oil. Lipid profiles were measured before and after the intervention, along with other data such as dietary habits, inflammatory markers, and functional capacity.
Results:
Dyslipidemia did not correlate with the patients' fat consumption. After the intervention, triglycerides (TG) levels were lower in IG compared to CG. This decrease was positively correlated with an improvement in functional disability (determined by the Expanded Disability Status Scale (EDSS)) and negatively with high-density cholesterol (HDL) and apolipoprotein A1. Significant and positive correlations were observed between EDSS and C-reactive protein (CRP) in the IG. These changes in the IG could be related to body fat decrease, whose percentage shows a positive correlation with CRP and TG levels, and a negative correlation with HDL levels.
Conclusions:
Patients with MS present a certain type of dyslipemia not associated with their nutritional habits. The administration of EGCG and coconut oil seems to decrease blood TG levels, which could explain the functional improvements.
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