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Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
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PTEN, PTENP1, microRNAs, and ceRNA Networks: Precision Targeting in Cancer Therapeutics

Glena Travis1, Eileen M McGowan1,2, Ann M Simpson3

  • 1Cancer Biology, Faculty of Science, School of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia.

Cancers
|October 28, 2023
PubMed
Summary

The PTENP1 pseudogene regulates PTEN tumor suppressor levels by acting as a ceRNA, sponging miRNAs. Dysregulation of this PTEN-miRNA-PTENP1 axis contributes to cancer, offering novel therapeutic avenues.

Keywords:
PTENPTENP1ceRNA networksmicroRNAsprecision therapy

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