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Related Experiment Video

Updated: Jul 12, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Polyploid Giant Cancer Cells Generated from Human Cytomegalovirus-Infected Prostate Epithelial Cells.

Fidaa Bouezzedine¹, Ranim El Baba¹, Sandy Haidar Ahmad¹

¹Pathogens & Inflammation/EPILAB Laboratory, EA 4266, University of Franche-Comté, 25000 Besançon, France.

|October 28, 2023

Summary

Human cytomegalovirus (HCMV) infection transforms prostate cells, promoting cancer hallmarks like stemness and EMT. This suggests HCMV may play a role in prostate cancer (PCa) development.

Keywords:

CIN PGCCs high-risk HCMV strains human cytomegalovirus oncogenesis prostate cancer stemness

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Formation of Human Prostate Epithelium Using Tissue Recombination of Rodent Urogenital Sinus Mesenchyme and Human Stem Cells

Published on: June 22, 2013

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Formation of Human Prostate Epithelium Using Tissue Recombination of Rodent Urogenital Sinus Mesenchyme and Human Stem Cells

Formation of Human Prostate Epithelium Using Tissue Recombination of Rodent Urogenital Sinus Mesenchyme and Human Stem Cells

Published on: June 22, 2013

Area of Science:

Oncology
Virology
Cellular Biology

Background:

Prostate cancer (PCa) is a leading cause of cancer death in men globally.
Chromosomal instability (CIN) and polyploid giant cancer cells (PGCCs) are linked to poor PCa prognosis.
Human cytomegalovirus (HCMV) has transforming potential, suggesting a possible role in PCa.

Purpose of the Study:

To investigate the role of high-risk HCMV clinical strains in transforming prostate epithelial cells.
To assess the molecular and cellular processes driving oncogenesis in HCMV-transformed cells.

Main Methods:

Utilizing high-risk HCMV clinical strains (DB and BL) to transform prostate epithelial cells.
Analyzing molecular markers (Myc, EZH2) and cellular features (stemness, EMT, PGCCs) in transformed cells.

Main Results:

HCMV infection induced sustained growth of transformed prostate epithelial cells (CTP cells).
CTP cells exhibited high expression of Myc and EZH2, characteristic of cancer stem cells.
Transformed cells displayed stemness, mesenchymal features, EMT, and formed PGCCs, promoting tumor development.

Conclusions:

HCMV-induced upregulation of Myc and EZH2, along with stemness and EMT traits, suggests HCMV's role in PCa development.
Targeting EZH2 and HCMV may offer potential therapeutic strategies for prostate cancer.