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Updated: Jul 12, 2025

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Castration-Resistant Prostate Cancer: From Uncovered Resistance Mechanisms to Current Treatments

Thi Khanh Le1,2, Quang Hieu Duong1,2,3, Virginie Baylot1,2

  • 1Centre de Recherche en Cancérologie de Marseille-CRCM, Inserm UMR1068, CNRS UMR7258, Aix-Marseille University U105, 13009 Marseille, France.

Cancers
|October 28, 2023
PubMed

Insights

Castration-resistant prostate cancer (CRPC) poses a significant challenge due to resistance mechanisms. This review details CRPC

Area of Science:

  • Oncology
  • Urology

Background:

  • Prostate cancer (PC) is a leading global cancer in men.
  • Castration-resistant prostate cancer (CRPC) presents a major clinical hurdle.
  • Mechanisms of resistance to androgen deprivation therapy (ADT) are complex.

Purpose of the Study:

  • To summarize CRPC's underlying resistance mechanisms.
  • To review current and emerging therapeutic strategies for CRPC.

Main Methods:

  • Literature review of mechanisms promoting CRPC.
  • Overview of approved CRPC treatments.

Main Results:

  • CRPC resistance involves AR-dependent and independent pathways.
  • Approved treatments include chemotherapy, immunotherapy, radiation, and PARP inhibitors.

Conclusions:

  • Understanding CRPC mechanisms is vital for treatment development.
  • Combination strategies and novel therapies are needed for improved patient outcomes.
Keywords:
PARP inhibitorsandrogen deprivation therapy (ADT)androgen signalingcastration-resistant prostate cancerchemotherapyimmunotherapyradionuclide therapy

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