Lanthanide-Based Organic Salts: Synthesis, Characterization, and Cytotoxicity Studies

Area of Science:

• Materials Science
• Inorganic Chemistry
• Supramolecular Chemistry

Background:

• Magnetic ionic liquids (MILs) offer unique properties by combining ionic liquid characteristics with magnetic behavior.
• Lanthanide ions, particularly Gadolinium(III) and Terbium(III), possess distinct magnetic properties valuable for advanced materials.

Purpose of the Study:

• To synthesize and characterize novel lanthanide-based magnetic ionic liquids using various cation families.
• To investigate the magnetic properties of these MILs and correlate them with their structural features.
• To evaluate the cytotoxicity of the synthesized lanthanide-based salts.

Main Methods:

• Synthesis of choline-family-based and other organic salts incorporating Gadolinium(III) and Terbium(III) anions.
• Characterization of the synthesized salts, including determination of melting temperatures.
• Measurement of magnetic moments for Gd(III) and Tb(III) containing salts.
• Cytotoxicity assays using cell lines (3T3, 293T, Caco2, HepG2).

Main Results:

• Successfully synthesized solid organic salts with melting points above 100 °C.
• Observed magnetic moments for Gd(III) salts ranged from 6.55-7.30 Bohr magnetons (MB), while Tb(III) salts ranged from 8.22-9.34 MB.
• Established a correlation between lanthanide magnetic moments and the cation's structural characteristics.
• Demonstrated that most prepared lanthanide-based salts exhibit low toxicity across tested cell lines.

Conclusions:

• Novel lanthanide-based magnetic ionic liquids were successfully prepared with tunable magnetic properties.
• The structural features of the cation significantly influence the magnetic moments of the lanthanide anions.
• The synthesized MILs show a favorable safety profile, indicating potential for applications where low toxicity is crucial.