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Updated: Jul 12, 2025
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Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
35.9K
Crystal Structure and Intermolecular Energy for Some Nandrolone Esters
Liviu Mare1, Marieta Muresan-Pop2, Pompilia Mioara Purcea Lopes1
1Physics & Chemistry Department, Technical University of Cluj-Napoca, 400114 Cluj-Napoca, Romania.
Molecules (Basel, Switzerland)
|October 28, 2023
Summary
This study determined the crystal structures of four nandrolone esters, revealing their packing and intermolecular interactions. Solubility was also investigated for pharmaceutical applications.
Area of Science:
- Biochemistry
- Crystallography
- Pharmaceutical Science
Background:
- Nandrolone, a testosterone derivative, is a naturally occurring anabolic-androgenic steroid.
- Esterification of nandrolone modifies its pharmacokinetic properties, impacting its pharmaceutical use.
Purpose of the Study:
- To determine the crystal structures of nandrolone propionate, phenylpropionate, cypionate, and undecanoate.
- To analyze the crystal packing, supramolecular features, and intermolecular interactions of these nandrolone esters.
- To evaluate the solubility of nandrolone esters for pharmaceutical relevance.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the crystal structures.
- Hirshfeld surface analysis was used for quantitative and qualitative assessment of intermolecular interactions.
- Crystal energies and intermolecular interactions were computationally evaluated.
- Solubility studies were conducted from a pharmaceutical perspective.
Main Results:
- The crystal structures of four nandrolone esters (propionate, phenylpropionate, cypionate, undecanoate) were successfully determined.
- Detailed analysis of crystal packing and supramolecular assemblies was performed using Hirshfeld surfaces.
- Intermolecular interactions and crystal energies were quantified, providing insights into solid-state stability.
- The solubility profiles of the different nandrolone esters were characterized.
Conclusions:
- The crystal structure and intermolecular interactions of nandrolone esters influence their solid-state properties.
- Understanding these interactions is crucial for predicting and optimizing the pharmaceutical behavior of nandrolone esters.
- This research provides a foundation for the rational design of nandrolone-based pharmaceutical formulations.
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