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Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
Crystal Structure and Intermolecular Energy for Some Nandrolone Esters
Liviu Mare1, Marieta Muresan-Pop2, Pompilia Mioara Purcea Lopes1
1Physics & Chemistry Department, Technical University of Cluj-Napoca, 400114 Cluj-Napoca, Romania.
Abstract:
Nandrolone (Estr-4-en-17β-ol-3-one) is a derivative of testosterone and a naturally occurring anabolic-androgenic agent which belongs to the steroid group. Crystal structures of four short, medium and long esterified forms of nandrolone, including propionate, phenylpropionate, cypionate and undecanoate were determined using single-crystal X-ray diffraction. Crystal packing, supramolecular features and intermolecular interactions were described based on a quantitative and qualitative Hirshfeld surfaces analysis accompanied by evaluation of crystal energies and intermolecular interactions computation. Also, the solubility of the esters was investigated from a pharmaceutical perspective.
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