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Hormone Receptor Signaling and Breast Cancer Resistance to Anti-Tumor Immunity

Alexandra Moisand1,2, Mathilde Madéry1,2, Thomas Boyer1,2

  • 1CNRS UMR 5164, ImmunoConcEpT, Biological and Medical Sciences Department, University of Bordeaux, 33076 Bordeaux, France.

International Journal of Molecular Sciences
|October 28, 2023
PubMed

Insights

Hormone receptor signaling in breast cancer impacts immune response. Modulating hormone pathways may enhance immunotherapy effectiveness for hormone-dependent breast cancers.

Area of Science:

  • Oncology
  • Immunology
  • Endocrinology

Background:

  • Breast cancer comprises diverse subtypes with variable treatment responses.
  • Hormone receptors (estrogen/progesterone) are present in 70-80% of breast cancers, influencing treatment strategies.
  • While immunotherapies show promise, their efficacy in breast cancer, particularly hormone-dependent types, remains limited.

Purpose of the Study:

  • To review the literature on estrogen receptor signaling in breast cancer.
  • To examine how hormone receptor modulation affects anti-tumor immunity and immune evasion.
  • To explore combining hormone therapy with immunotherapy for improved breast cancer treatment.

Main Methods:

  • Literature review of studies on hormone receptor signaling and breast cancer immunity.
  • Analysis of estrogen receptor's role in immune sensitivity and escape mechanisms.
  • Discussion of potential therapeutic strategies combining hormone and immune therapies.

Main Results:

  • Estrogen receptor signaling influences breast cancer cell sensitivity to anti-tumor immune responses.
  • Hormone-dependent breast cancers may exhibit distinct immune evasion strategies.
  • Current immunotherapies are less effective in hormone-dependent breast cancers.

Conclusions:

  • Estrogen receptor signaling is a critical factor in breast cancer's interaction with the immune system.
  • Targeting hormone pathways could potentially enhance the efficacy of cancer immunotherapies.
  • Further research is needed to optimize combination therapies for hormone-dependent breast cancers.
Keywords:
breast cancerscancer immunityestrogen receptorshormone receptorshormone signalingimmunotherapies

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