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Overview of Recent Advances in Nano-Based Ocular Drug Delivery
Li-Ching Liu1, Yi-Hao Chen1, Da-Wen Lu1
1Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
International Journal of Molecular Sciences
|October 28, 2023
Summary
This review explores nano-based drug delivery systems for ocular diseases, detailing various systems and their clinical applications. Further research is needed to ensure the safety and efficacy of these advanced ophthalmic formulations.
Area of Science:
- Ophthalmology
- Biomaterial Science
- Clinical Pharmacology
- Nanotechnology
Background:
- Ocular diseases significantly affect vision and quality of life globally.
- Effective ocular drug delivery is hindered by the eye's unique anatomical and physiological barriers.
- Nano-based drug delivery offers potential solutions to overcome these challenges.
Purpose of the Study:
- To review the anatomical and physiological barriers of the eye relevant to drug delivery.
- To provide a comprehensive overview of various nano-based drug delivery systems for ophthalmic applications.
- To discuss the clinical applications, advantages, and challenges of these systems.
Main Methods:
- Literature review of nano-based ocular drug delivery systems.
- Analysis of anatomical and physiological barriers in ocular drug administration.
- Evaluation of nanomicelles, nanoparticles, liposomes, hydrogels, and gene therapy approaches.
Main Results:
- Detailed examination of diverse nano-based systems including nanoparticles, liposomes, hydrogels, and microneedles.
- Overview of clinical applications and advancements in nano-based ocular delivery over the last decade.
- Identification of advantages and challenges associated with current nano-based ophthalmic formulations.
Conclusions:
- Nano-based drug delivery systems show promise for treating ocular diseases.
- Further research is essential to address safety and toxicity concerns for clinical translation.
- Continued investigation is crucial for optimizing nano-delivery for enhanced ophthalmic drug efficacy.
Keywords:
nano-based drug delivery systemnanocarriersocular barriersocular bioavailabilityocular drug deliveryMore Related Videos
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