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Related Experiment Videos

Induced atrophic rhinitis in rats.

T G Kimman, E M Kamp

    American Journal of Veterinary Research
    |November 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Bordetella bronchiseptica readily colonizes rat nasal passages, causing turbinate atrophy and inflammation. Pasteurella multocida showed poor colonization, even with Bordetella bronchiseptica co-infection.

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    Area of Science:

    • Veterinary Pathology
    • Microbiology
    • Immunology

    Background:

    • Bordetella bronchiseptica and Pasteurella multocida are common respiratory pathogens in various animal species.
    • Understanding their colonization patterns and pathogenic effects is crucial for animal health management.
    • Atrophic rhinitis, a significant disease, involves nasal turbinate damage.

    Purpose of the Study:

    • To investigate the colonization dynamics of Bordetella bronchiseptica and Pasteurella multocida in newborn rats.
    • To assess the impact of these bacterial infections on nasal turbinate structure and inflammation.
    • To determine the role of Bordetella bronchiseptica in facilitating Pasteurella multocida colonization.

    Main Methods:

    • Newborn specific-pathogen-free rats were inoculated with Bordetella bronchiseptica and/or Pasteurella multocida.

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  • Nasal cavity colonization was assessed.
  • Serum agglutinating antibodies against B. bronchiseptica were measured.
  • Turbinate atrophy was quantified by measuring the osseous core length of ventral turbinates.

    • Main Results:

    • Bordetella bronchiseptica efficiently colonized the nasal cavity and induced specific antibodies.
    • Significant turbinate atrophy and severe inflammatory reactions were observed following dual inoculation or high-dose B. bronchiseptica inoculation.
    • Pasteurella multocida exhibited very limited colonization, irrespective of prior B. bronchiseptica or acetic acid treatment.

    Conclusions:

    • Bordetella bronchiseptica is a primary colonizer of the rat nasal cavity, leading to significant pathology.
    • Pasteurella multocida's colonization is restricted and not enhanced by B. bronchiseptica presence.
    • These findings highlight the distinct pathogenic potentials of these two bacteria in a neonatal rat model.