Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

22
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
22
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

11
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
11
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

10
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
10
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

11
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
11
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

9
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
9
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

10
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
10

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Programmed Death Ligand 1 (PD-L1) and Tumor-Associated Macrophages in Gastric-Type Hepatocellular Carcinoma: Prognostic Insights.

International journal of molecular sciences·2026
Same author

Decoding Cervical Neuroendocrine Carcinoma: A Practical Review of Diagnostic Pitfalls, Differential Diagnosis and Molecular Insights.

Diagnostics (Basel, Switzerland)·2026
Same author

FGFR2b in Gastric Cancer: Translating a Therapeutic Target into a Reliable Biomarker.

Cancers·2026
Same author

Standardized Perioperative Thrombosis Prevention in Neonatal Modified Blalock-Taussig Shunt Surgery: An Algorithm-Based Single-Center Case Series.

Children (Basel, Switzerland)·2026
Same author

From Primary Tumor to Peritoneal Niche: Microenvironmental Divergence in Gastric Cancer Peritoneal Metastasis.

Cells·2026
Same author

HER2-Low Gastric and Gastroesophageal Junction Adenocarcinoma: From Assessment to Treatment Strategies.

International journal of molecular sciences·2026

Related Experiment Video

Updated: Jul 12, 2025

Isolation and Excision of Murine Aorta; A Versatile Technique in the Study of Cardiovascular Disease
07:25

Isolation and Excision of Murine Aorta; A Versatile Technique in the Study of Cardiovascular Disease

Published on: November 24, 2014

32.7K

Histopathological Gap in Aortic Diseases: A Prospective Analysis.

Cosmin Marian Banceu1,2,3, Simona Gurzu4,5,6, Catalin-Bogdan Satala4

  • 1I.O.S.U.D., George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania.

International Journal of Molecular Sciences
|October 28, 2023
PubMed
Summary

Histological changes in the aorta wall differ between aortic aneurysm and aortic dissection. Medial degeneration predicts aortic dissection and impacts patient mortality, suggesting routine histopathological evaluation post-surgery.

Keywords:
aortic aneurysmaortic dissectionhistologymyxomatoussurgical replacement

More Related Videos

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 7, 2013

13.8K
Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

947

Related Experiment Videos

Last Updated: Jul 12, 2025

Isolation and Excision of Murine Aorta; A Versatile Technique in the Study of Cardiovascular Disease
07:25

Isolation and Excision of Murine Aorta; A Versatile Technique in the Study of Cardiovascular Disease

Published on: November 24, 2014

32.7K
Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 7, 2013

13.8K
Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

947

Area of Science:

  • Cardiovascular Pathology
  • Aortic Disease Research
  • Surgical Histopathology

Background:

  • Aortic dissection (AD) is a life-threatening cardiovascular emergency.
  • Aortic aneurysms (AA) share risk factors and pathological pathways with AD.
  • Understanding histological differences is crucial for risk stratification and management.

Purpose of the Study:

  • To compare histological changes in the aorta wall between patients with AD and AA.
  • To identify histological predictors of AD development.
  • To assess the prognostic value of aortic wall histopathology in surgical patients.

Main Methods:

  • Histopathological analysis of aortic tissue samples from patients undergoing surgical aortic replacement.
  • Comparison of specific histological features (medial layer, myxomatous changes, subendothelial degeneration) between AD and AA groups.
  • Statistical analysis to determine significant differences and predictive values.

Main Results:

  • Aortic aneurysm samples showed significantly more media layer modifications, myxomatous changes, and subendothelial degeneration than AD samples.
  • Patients with AA were twice as likely to exhibit histological changes compared to AD patients.
  • Moderate to severe medial degeneration was a strong predictor of developing AD.

Conclusions:

  • Histopathological scoring of aortic tissue is a valuable predictor of mortality in patients undergoing aortic replacement.
  • Routine histopathological evaluation should be standardized for patients undergoing aortic surgery.
  • Findings may guide individualized postoperative management based on aortic wall pathology.