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Oncomeric Profiles of microRNAs as New Therapeutic Targets for Treatment of Ewing's Sarcoma: A Composite Review

Mubashir Hassan1, Saba Shahzadi1, Amal Malik2

  • 1The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children Hospital, Columbus, OH 43205, USA.

Genes
|October 28, 2023
PubMed

Insights

microRNAs show promise as diagnostic and therapeutic tools for Ewing sarcoma (ES), a rare bone cancer affecting young people. This review explores microRNAs as potential targets to improve ES treatment outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarkers

Background:

  • Ewing sarcoma (ES) is a rare bone and soft tissue cancer predominantly affecting children and young adults.
  • Current ES treatments, including chemotherapy, radiation, and surgery, have limitations.
  • microRNAs (miRNAs) are emerging as significant players in cancer development and progression.

Purpose of the Study:

  • To review the potential of microRNAs as diagnostic and prognostic biomarkers for Ewing sarcoma.
  • To explore the therapeutic potential of microRNAs as novel treatment targets for ES.
  • To identify specific microRNAs involved in molecular pathways critical to ES progression.

Main Methods:

  • Comprehensive data mining of existing literature and databases.
  • Analysis of microRNA involvement in cancer-related molecular pathways.
  • Evaluation of microRNAs as potential therapeutic agents.

Main Results:

  • microRNAs have demonstrated utility as biomarkers in various cancers.
  • miRNAs are implicated in the dysregulation of pathways controlling tumor progression, invasion, angiogenesis, and metastasis.
  • Specific microRNAs show potential for targeted therapeutic intervention in ES.

Conclusions:

  • microRNAs represent a promising avenue for improving Ewing sarcoma diagnosis and prognosis.
  • Targeting specific microRNAs could offer novel therapeutic strategies for ES.
  • Further research into microRNA-based therapies is warranted for Ewing sarcoma.
Keywords:
EWSR1Ewing’s sarcomamiRNAtherapeutic targets

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