APOE Polymorphism Is Associated with Changes in the Kynurenine Pathway.
Per G Farup1,2, Helge Rootwelt3, Knut Hestad1,4
1Department of Research, Innlandet Hospital Trust, 2381 Brumunddal, Norway.
Genes
|October 28, 2023
Summary
The study found that APOE gene variations influence the Kynurenine pathway (KP) metabolites, potentially linking inflammation to diseases associated with APOE. This research sheds light on APOE polymorphism and KP interactions.
Area of Science:
- Neuroscience
- Genetics
- Metabolomics
Background:
- APOE polymorphism is linked to various disorders.
- The Kynurenine pathway (KP) is implicated in numerous diseases.
- The relationship between APOE polymorphism and the KP remains largely unexplored.
Purpose of the Study:
- To investigate the association between APOE genotypes and KP metabolites.
- To explore the role of the KP in disorders linked to APOE polymorphism.
Main Methods:
- Included subjects with morbid obesity, depression, and neurological symptoms.
- Classified APOE genotypes into E2, E3, and E4 groups.
- Quantified serum levels of KP metabolites: Tryptophan, Kynurenine, Kynurenic acid, Quinolinic acid, and Xanthurenic acid.
Main Results:
- A significant positive association was observed between the E3 genotype and Quinolinic acid levels.
- A significant negative association was found between the E4 genotype and Kynurenine levels.
- Quinolinic acid is associated with neurotoxicity and inflammation; Kynurenine is an inflammation marker.
Conclusions:
- APOE polymorphism may alter the KP, contributing to disease development.
- Inflammation is suggested as a potential mediator linking APOE and the KP.
Keywords:
APOEdepressioninflammationkynureninekynurenine pathwayneurological symptomsobesityquinolinic acidMore Related Videos
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