Update on Obesity in Psoriasis Patients

Area of Science:

• Dermatology
• Immunology
• Metabolic Diseases

Background:

• Psoriasis is a chronic inflammatory skin disease influenced by genetic, epigenetic, environmental, and lifestyle factors.
• Severe psoriasis significantly impacts quality of life, comparable to chronic conditions like diabetes and depression.
• An increasing incidence of autoimmune diseases, including psoriasis, overlaps with rising obesity rates.

Purpose of the Study:

• To explore the bidirectional relationship between psoriasis and obesity.
• To investigate the role of adipokines and the human microbiome in the pathogenesis of psoriasis in obese individuals.

Main Methods:

• Review of current research on psoriasis and obesity.
• Analysis of studies investigating adipokines secreted by adipose tissue.
• Examination of research identifying specific human microbiome patterns associated with obesity and psoriasis.

Main Results:

• Psoriasis and obesity exhibit a two-way association, where each condition can exacerbate the other.
• Elevated levels of specific adipokines in obese psoriasis patients suggest shared pathogenic mechanisms.
• Distinct human microbiome patterns are identified in individuals with obesity and psoriasis.

Conclusions:

• The interplay between psoriasis and obesity is complex, involving shared molecular pathways and microbial influences.
• Obesity affects psoriasis treatment response and adverse events, potentially decreasing patient compliance.
• Targeting specific microbiome patterns presents a potential future therapeutic strategy for select individuals with psoriasis and obesity.