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The Ratio of Monocytes to HDL-Cholesterol Is Associated with Cardiovascular Risk and Insulin Resistance in Patients

Alejandro Romo-Cordero1, Marta González-Sierra2, Juan Carlos Quevedo-Abeledo3

  • 1Division of Internal Medicine, Hospital Universitario de Canarias, 38320 Tenerife, Spain.

Life (Basel, Switzerland)
|October 28, 2023
PubMed

Insights

The monocytes to HDL-cholesterol ratio (MHR) does not differ between rheumatoid arthritis patients and controls. However, MHR is linked to increased cardiovascular risk and insulin resistance in RA patients.

Area of Science:

  • Cardiology
  • Rheumatology
  • Biomarkers

Background:

  • The monocytes to HDL-cholesterol ratio (MHR) is an inflammation marker associated with cardiovascular mortality.
  • Rheumatoid arthritis (RA) confers an augmented risk of cardiovascular disease.
  • The role of MHR in RA cardiovascular risk remains uninvestigated.

Purpose of the Study:

  • To investigate the relationship between MHR and cardiovascular risk in RA patients.
  • To explore the association of MHR with RA disease characteristics and traditional cardiovascular risk factors.

Main Methods:

  • A cross-sectional study included 430 RA patients and 208 controls.
  • Evaluated complete blood cell count and lipid profiles.
  • Multivariable analysis assessed MHR in relation to RA features, subclinical atherosclerosis, insulin resistance, and beta cell function.

Main Results:

  • MHR did not significantly differ between RA patients and controls after multivariable adjustment.
  • MHR showed a poor relationship with most RA disease characteristics, except for ESR.
  • MHR positively correlated with cardiovascular risk (SCORE2) and insulin resistance in RA patients.

Conclusions:

  • MHR is not a distinguishing biomarker between RA patients and healthy controls.
  • MHR demonstrates a significant association with heightened cardiovascular risk and insulin resistance in RA.
  • Further research is warranted to understand MHR's role in RA pathophysiology and cardiovascular complications.

Keywords:
SCORE2insulin resistancemonocyte to high-density lipoprotein cholesterolrheumatoid arthritis

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