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Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection
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The CHA2DS2-VASC Score Predicts Mortality in Patients Undergoing Coronary Angiography

Nicholay Teodorovich1, Gera Gandelman1, Michael Jonas1

  • 1Kaplan Medical Center, Rehovot and the Hebrew University, Jerusalem 7661041, Israel.

Life (Basel, Switzerland)
|October 28, 2023
PubMed

Insights

The CHA2DS2-VASc score predicts mortality in patients undergoing coronary angiography. A higher score (≥4) independently indicates increased mortality risk, suggesting its use in initial patient screening.

Area of Science:

  • Cardiology
  • Clinical Risk Stratification

Background:

  • The CHA2DS2-VASc score is established for predicting thromboembolic risk in atrial fibrillation (AF).
  • Its utility in predicting mortality in patients undergoing coronary angiography is not well-defined.

Purpose of the Study:

  • To investigate the CHA2DS2-VASc score's ability to predict mortality in patients undergoing coronary angiography.

Main Methods:

  • Prospective study of 990 patients undergoing coronary angiography.
  • Patients stratified by CHA2DS2-VASc score (<4 vs. ≥4).
  • Kaplan-Meier analysis and Cox regression modeling used to assess mortality risk.

Main Results:

  • A CHA2DS2-VASc score ≥4 was associated with significantly higher all-cause mortality (38.7% vs. 13.1%, p < 0.0001).
  • This association persisted across subgroups including those with and without AF, varying LVEF, and renal function.
  • An elevated CHA2DS2-VASc score (≥4) was an independent predictor of mortality (HR 2.12, p = 0.001).

Conclusions:

  • The CHA2DS2-VASc score is a simple and reliable predictor of mortality in patients undergoing coronary angiography.
  • It can be utilized for initial screening to identify high-risk individuals.
Abstract

Keywords:
CHA2DS2-VASC scorecoronary angiographymortalityoutcomes

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