Multimodality Cardiovascular Imaging of Cardiotoxicity Due to Cancer Therapy

Area of Science:

• Cardiology
• Oncology
• Medical Imaging

Background:

• Cancer therapies improve survival but pose cardiotoxicity risks.
• Current guidelines lack empirical basis for managing cardiotoxicity.
• Effective monitoring is crucial for patients undergoing cancer treatment.

Purpose of the Study:

• To explore the relationship between cancer therapy and cardiovascular health.
• To highlight the role of advanced multimodality imaging in monitoring cardiotoxicity.
• To review cardiovascular effects of various cancer therapies and associated conditions.

Main Methods:

• Review of cardiovascular effects of different cancer therapy classes.
• Detailed analysis of advanced imaging modalities: echocardiography, cardiac MRI, CT, and nuclear imaging.
• Exploration of cardiotoxic conditions including cardiac dysfunction, myocarditis, and heart failure.

Main Results:

• Cancer therapies have dose- and time-dependent cardiovascular impacts.
• Multimodality imaging offers diverse strengths and limitations for monitoring.
• Identified cardiotoxic conditions include cardiac dysfunction, myocarditis, and heart failure with preserved ejection fraction.

Conclusions:

• Advanced multimodality imaging is essential for monitoring cancer therapy-related cardiotoxicity.
• Understanding cardiotoxic effects guides clinical management and long-term follow-up.
• Future research should focus on optimizing surveillance and management strategies for cancer survivors.