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Nanocarriers in Tuberculosis Treatment: Challenges and Delivery Strategies
Mahesh Kumar1, Tarun Virmani1, Girish Kumar1
1School of Pharmaceutical Sciences, Modern Vidya Niketan University, Palwal 121105, India.
Pharmaceuticals (Basel, Switzerland)
|October 28, 2023
Summary
Nanotechnology offers a novel approach to treating tuberculosis (TB), a leading infectious killer. Nanocarriers improve drug delivery, reducing side effects and enhancing patient compliance for more effective TB treatment.
Area of Science:
- Biomedical Engineering
- Nanomedicine
- Infectious Diseases
Background:
- Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a major global health threat.
- Conventional TB treatments face challenges including drug resistance (MDR/XDR strains), long durations, and poor patient compliance.
- Emerging drug-resistant TB strains necessitate innovative therapeutic strategies.
Purpose of the Study:
- To review the application of nanotechnology in developing novel treatments for tuberculosis.
- To explore the potential of nanocarriers for targeted delivery of anti-TB drugs.
- To highlight the advantages and future prospects of nanomedicine in combating TB.
Main Methods:
- Review of scientific literature and patent databases focusing on nanocarrier-based TB therapies.
- Analysis of different types of nanocarriers used for anti-TB drug delivery (e.g., lipid nanoparticles, liposomes).
- Investigation of ligand-targeted nanocarriers for enhanced drug specificity.
Main Results:
- Nanocarriers demonstrate potential for targeted delivery of anti-TB drugs, improving efficacy.
- Benefits include reduced drug dosage, minimized side effects, enhanced solubility and bioavailability.
- Ligand conjugation (e.g., mannose, hyaluronic acid) further refines nanocarrier targeting.
- Several nanocarrier formulations and related patents show promise for TB treatment.
Conclusions:
- Nanotechnology presents a promising avenue for overcoming limitations of conventional TB treatments.
- Nanocarrier-based drug delivery systems can significantly improve treatment outcomes and patient compliance.
- Further research and development in nanomedicine are crucial for advancing TB control strategies.
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