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Unlocking the Power of Onion Peel Extracts: Antimicrobial and Anti-Inflammatory Effects Improve Wound Healing through

Rafik Mounir1, Walaa A Alshareef2, Eman A El Gebaly2

  • 1Pharmacognosy Department, Faculty of Pharmacy, Misr University for Science and Technology, Giza 12585, Egypt.

Pharmaceuticals (Basel, Switzerland)
|October 28, 2023
PubMed

Insights

Onion peels, rich in phenolics, show potential for wound healing. Red onion extract fights bacteria and fungal infections, while yellow onion extract significantly promotes skin tissue regeneration by reducing inflammation.

Area of Science:

  • Food Science
  • Pharmacology
  • Dermatology

Background:

  • Onion peels are abundant food by-products rich in bioactive phenolics.
  • These peels are often discarded, representing a valuable, underutilized resource.

Purpose of the Study:

  • To analyze the metabolomic profiles of red (RO) and yellow (YO) onion peel extracts.
  • To evaluate the in vitro and in vivo wound healing properties of these extracts, including anti-inflammatory, antimicrobial, and regenerative effects.

Main Methods:

  • UPLC-MS/MS for metabolomic profiling.
  • In vitro assays (SRB, Griess, antimicrobial tests) and in vivo studies (histology, immunohistochemistry, ELISA) on excisional skin wounds and Candida albicans infection.
  • Analysis of signaling pathways (NLRP3/caspase-1, Notch-1) and angiogenesis (VEGF).

Main Results:

  • RO extract exhibited antibacterial and antifungal activity, with quercetin and anthocyanin derivatives contributing to improved skin appearance.
  • Both extracts reduced nitric oxide release in vitro with negligible cytotoxicity.
  • YO extract demonstrated superior in vivo tissue regeneration, suppressing NLRP3/caspase-1, reducing inflammatory cytokines, decreasing Notch-1, and promoting VEGF-mediated angiogenesis.

Conclusions:

  • Onion peel extracts possess significant therapeutic potential for wound treatment.
  • They effectively combat microbial infections, reduce inflammation, and promote tissue regeneration, highlighting their value as a sustainable source of bioactive compounds.
Keywords:
CandidaMRSAVEGFangiogenesisanthocyaninsdietary flavonoidsquercetintissue regeneration

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