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Redrawing Urokinase Receptor (uPAR) Signaling with Cancer Driver Genes for Exploring Possible Anti-Cancer Targets and
Yu-Ching Chang1, Chung-Ze Wu2,3, Chao-Wen Cheng4,5
1Graduate Institute of Life Sciences, National Defense Medical Center, Taipei City 114201, Taiwan.
Pharmaceuticals (Basel, Switzerland)
|October 28, 2023
Summary
Urokinase receptor (uPAR) signaling is crucial in cancer progression. This study maps uPAR pathways using cancer driver genes, identifying receptor tyrosine kinases and ribosomal S6 kinases as key mediators for novel anti-cancer drug development.
Area of Science:
- Oncology
- Molecular Biology
- Bioinformatics
Background:
- Urokinase (uPA) and its receptor (uPAR) are vital in cancer progression.
- Understanding uPA/uPAR signaling crosstalk is key for cancer therapy.
Purpose of the Study:
- To map uPAR signaling pathways using cancer driver genes.
- To identify druggable targets for novel anti-cancer treatments.
Main Methods:
- Integrated bioinformatics approach: modulator identification, gene ontology networking, protein target prediction, pathway analysis.
- Construction of a uPAR modulator screening platform.
- In silico virtual screening and development of a uPAR-driver gene pair rule.
Main Results:
- uPAR signaling interacts with 10 KEGG cancer pathways.
- Receptor tyrosine kinases (RTKs) and ribosomal S6 kinases (RSKs) act as signal hubs for uPAR-mediated cancer hallmarks.
- An in silico screening platform and a predictive rule for uPAR modulators were established.
Conclusions:
- Elucidated the complex network between uPAR modulation and cancer.
- Paved the way for developing new chemical entities or repositioning existing drugs against cancer.
Keywords:
a pharmaceutical bioinformatics studycancer driver genenetwork analysisuPAR modulatoruPAR-mediated signaling systemMore Related Videos
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