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Related Concept Videos

Labeling DNA Probes03:31

Labeling DNA Probes

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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In-situ Hybridization02:31

In-situ Hybridization

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In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
Types of probes and labels
A probe is a complementary strand of DNA or RNA that binds to corresponding nucleotide sequences in a cell. Many...
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Novel Imaging Probes: From Design to Applications.

Kuo-Ting Chen1

  • 1Department of Chemistry, National Dong Hwa University, Hualien 974301, Taiwan.

Pharmaceuticals (Basel, Switzerland)
|October 28, 2023
PubMed
Summary

Molecular imaging offers advanced clinical diagnosis capabilities. This technology provides crucial insights for disease detection and treatment monitoring.

Area of Science:

  • Molecular imaging
  • Biomedical engineering
  • Radiochemistry

Background:

  • Molecular imaging is a rapidly advancing field.
  • It enables non-invasive visualization of biological processes at the molecular and cellular levels.
  • Clinical diagnosis relies on accurate and early detection of diseases.

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