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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Related Experiment Video

Updated: Jul 12, 2025

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

Folate-Targeted Nanoliposomal Chemophototherapy.

Upendra Chitgupi¹, Yiru Qin¹, Sanjana Ghosh¹

¹Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

|October 28, 2023

Summary

This summary is machine-generated.

Folic acid-conjugated liposomes loaded with chemotherapy drugs show potential for cancer treatment. Light-activated drug release from these liposomes effectively delayed tumor growth in mice.

Keywords:

chemophototherapy doxorubicin folate folic acid liposome photodynamic therapy

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Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

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Published on: February 9, 2019

Area of Science:

Biomedical Engineering
Nanotechnology
Cancer Therapeutics

Background:

Light-responsive liposomes enable on-demand drug release for enhanced cancer therapy.
Efficient delivery of chemotherapeutics to tumors for theranostics remains a significant challenge.

Purpose of the Study:

To evaluate folic acid-conjugated, light-sensitive porphyrin-phospholipid (PoP) liposomes for targeted chemophototherapy (CPT) of cancer.
To assess the efficacy of Doxorubicin (Dox)-loaded FA-PoP liposomes in vitro and in vivo.

Main Methods:

PoP liposomes and FA-PoP liposomes were synthesized and loaded with Doxorubicin.
In vitro studies involved incubating liposomes with human KB cancer cells overexpressing folate receptors.
In vivo studies utilized mice bearing subcutaneous KB tumors treated with liposomes and laser irradiation.

Main Results:

FA-PoP liposomes demonstrated increased uptake by FA receptor-overexpressing cancer cells compared to non-targeted PoP liposomes.
Both Dox and PoP contributed to chemophototherapy, with liposomes inducing cancer cell death in vitro.
In vivo, Dox-loaded PoP and FA-PoP liposomes, combined with laser treatment, delayed tumor growth and improved survival in mice.
Laser irradiation enhanced Dox delivery to tumors for both liposome formulations.

Conclusions:

Doxorubicin-loaded FA-PoP liposomes are effective for cancer treatment when administered systemically and activated by local light irradiation.
The folic acid targeting moiety was not essential for the observed anti-tumor responses in this specific tumor model.