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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Natural Polymer-Based Hydrogels: From Polymer to Biomedical Applications.

Lingling Zhao1, Yifan Zhou1, Jiaying Zhang1,2

  • 1School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China.

Pharmaceutics
|October 28, 2023
PubMed
Summary

Natural polymer hydrogels offer excellent biocompatibility for biomedical uses like drug delivery and wound healing. Innovations in materials and fabrication methods are advancing their applications in regenerative medicine.

Keywords:
drug deliveryhydrogelnatural polymertissue engineeringwound healing

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Natural polymers are widely used for hydrogel preparation due to their biocompatibility, degradability, and flexibility.
  • Common natural polymers include cellulose, chitosan, collagen/gelatin, alginate, hyaluronic acid, starch, guar gum, agarose, and dextran.

Purpose of the Study:

  • To review natural polymers used in hydrogel preparation.
  • To elaborate on hydrogel formation, properties, and biomedical applications.
  • To discuss future perspectives for natural polymers and their hydrogels.

Main Methods:

  • Literature review of natural polymers and their hydrogel applications.
  • Illustration of polymeric structures and synthesis processes.
  • Summary of biomedical applications in drug delivery, tissue regeneration, and wound healing.

Main Results:

  • Natural polymer-based hydrogels exhibit significant potential in various biomedical fields.
  • Novel hydrogel materials (e.g., double-network, composite hydrogels, microrobots) and fabrication strategies (e.g., 3D/4D bioprinting) are emerging.
  • Advancements in enzymatic and biological methods enhance natural polymer properties.

Conclusions:

  • Natural polymer hydrogels are increasingly important in biomedical applications.
  • Development of high-performance natural polymers and advanced hydrogel fabrication techniques is crucial.
  • Further research is needed to overcome challenges and unlock the full potential of these materials.