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Related Concept Videos

Experimental RNAi02:15

Experimental RNAi

6.1K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
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RNA Interference01:23

RNA Interference

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
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Subviral Agents01:29

Subviral Agents

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Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
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Related Experiment Video

Updated: Jul 12, 2025

RNA Interference in Aquatic Beetles as a Powerful Tool for Manipulating Gene Expression at Specific Developmental Time Points
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RNA Interference in Aquatic Beetles as a Powerful Tool for Manipulating Gene Expression at Specific Developmental Time Points

Published on: May 29, 2020

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RNAi-Based Therapy: Combating Shrimp Viral Diseases.

Md Shahanoor Alam1, Mohammad Nazrul Islam2, Mousumi Das3

  • 1Department of Genetics and Fish Breeding, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur 1706, Bangladesh.

Viruses
|October 28, 2023
PubMed
Summary

RNA interference (RNAi) offers a promising solution to combat shrimp viral diseases, a major threat to aquaculture. This technology silences viral genes, providing a sustainable and effective disease control method.

Keywords:
dsRNAinnate immune responsepenaeid shrimppost-transcriptional gene silencingshrimp viral diseasessiRNAtherapeutics

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Double-stranded RNA Oral Delivery Methods to Induce RNA Interference in Phloem and Plant-sap-feeding Hemipteran Insects
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Bacterial Delivery of RNAi Effectors: Transkingdom RNAi
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Bacterial Delivery of RNAi Effectors: Transkingdom RNAi

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Last Updated: Jul 12, 2025

RNA Interference in Aquatic Beetles as a Powerful Tool for Manipulating Gene Expression at Specific Developmental Time Points
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Double-stranded RNA Oral Delivery Methods to Induce RNA Interference in Phloem and Plant-sap-feeding Hemipteran Insects
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Bacterial Delivery of RNAi Effectors: Transkingdom RNAi
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Area of Science:

  • Aquaculture
  • Molecular Biology
  • Veterinary Science

Background:

  • Shrimp aquaculture is crucial for global seafood supply.
  • Viral diseases cause significant economic losses in shrimp farming.
  • Conventional treatments are ineffective against shrimp viral pathogens.

Purpose of the Study:

  • To review RNA interference (RNAi) therapy for shrimp viral diseases.
  • To explore RNAi's potential as a sustainable solution.
  • To discuss current progress, challenges, and prospects of RNAi in shrimp health.

Main Methods:

  • Review of existing scientific literature on RNAi technology.
  • Analysis of RNAi's application in combating viral infections in model organisms.
  • Examination of studies on RNAi-based therapy for shrimp viral diseases.

Main Results:

  • RNA interference effectively silences specific viral genes, inhibiting viral replication.
  • RNAi-based therapies have shown success in various model organisms.
  • RNAi presents a precise, sustainable, and environmentally friendly approach to shrimp disease management.

Conclusions:

  • RNA interference technology holds significant potential to revolutionize shrimp disease control.
  • Further research and development are needed to overcome challenges and fully implement RNAi-based therapies in aquaculture.
  • RNAi offers a sustainable and effective strategy to mitigate economic losses from shrimp viral diseases.