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Implementation strategy modifications: An applied multi-site comparison using ERIC and FRAME-IS for the "Fluoroquinolone Restriction for the Prevention of <i>Clostridioides difficile</i> infection Trial" (FIRST).

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Updated: Jul 12, 2025

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
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Understanding clinical implementation coordinators' experiences in deploying evidence-based interventions.

Sara E Hernandez1, Demetrius Solomon2, Jukrin Moon1

  • 1School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA.

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
|October 28, 2023
PubMed
Summary
This summary is machine-generated.

Clinical implementation coordinators are key to implementing antibiotic stewardship interventions like fluoroquinolone restrictions. They faced barriers like staffing and COVID-19 but succeeded through collaboration and empowerment.

Keywords:
antibiotic stewardshipbest-practice alertclinical decision support systemsimplementation sciencemiddle management

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Area of Science:

  • Healthcare management
  • Antibiotic stewardship
  • Clinical implementation science

Background:

  • The fluoroquinolone restriction for the prevention of Clostridioides difficile infection (FIRST) trial aimed to optimize fluoroquinolone use.
  • Clinical implementation coordinators (CICs) within antibiotic stewardship teams (ASTs) are crucial for implementing evidence-based interventions.
  • Understanding the CIC role is essential for successful healthcare innovation adoption.

Purpose of the Study:

  • To describe the roles and responsibilities of CICs within ASTs.
  • To identify facilitators and barriers encountered by CICs during the implementation process.

Main Methods:

  • Directed content analysis of semistructured interviews, implementation diaries, and check-in meetings.
  • Utilized a conceptual framework of middle managers' roles in healthcare innovation implementation.

Main Results:

  • CICs performed diverse roles: information gathering for best-practice alerts (BPAs), staff preparation, meeting organization, stakeholder engagement, and clinical evaluation.
  • Key barriers included organizational staffing models and COVID-19 interruptions.
  • Facilitators comprised AST empowerment, positive staff relationships, and diverse implementation strategies.

Conclusions:

  • CICs significantly facilitate healthcare innovation implementation through their roles and responsibilities.
  • CICs act as strategic partners, enhancing the adoption and sustainability of antibiotic stewardship protocols, such as fluoroquinolone preauthorization.