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Feline morbillivirus infection associated with fatal encephalitis in a Bengal cat

Kara L D Dawson1, Nicole Wildi1, Mauro Cavalli2

  • 1Division of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Journal of Veterinary Internal Medicine
|October 28, 2023
PubMed

Insights

Feline morbillivirus (FeMV) was detected in a cat brain with encephalitis. This finding highlights FeMV's neurotropism and potential role in feline neurological disease.

Area of Science:

  • Veterinary Virology
  • Neurovirology
  • Molecular Epidemiology

Background:

  • Feline morbillivirus (FeMV) is a recently identified paramyxovirus.
  • Paramyxoviruses are known for high contagion and zoonotic potential.
  • Understanding FeMV's role in feline disease is crucial.

Observation:

  • FeMV was detected in archived brain tissue from a young Bengal cat with nonsuppurative encephalitis.
  • High-throughput sequencing (HTS) enabled full-length FeMV genome recovery.
  • Phylogenetic analysis placed the strain within FeMV genotype 1.

Findings:

  • FeMV RNA was detected in brain lesions using in situ hybridization (ISH).
  • The study demonstrates FeMV's neurotropism.
  • FeMV is associated with encephalitis in cats.

Implications:

  • This research provides deeper insight into FeMV pathogenesis.
  • Further studies are warranted to explore FeMV's epidemiology and impact on feline health.
  • The zoonotic potential of FeMV requires continued investigation.
Keywords:
feline encephalitisfeline morbillivirusmetagenomicsneurology

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