ViralZone 2024 provides higher-resolution images and advanced virus-specific resources
Edouard De Castro1, Chantal Hulo1, Patrick Masson1
1Swiss-Prot group, SIB Swiss Institute of Bioinformatics, CMU, 1 Michel Servet, 1211 Geneva 4, Switzerland.
Nucleic Acids Research
|October 28, 2023
Summary
ViralZone enhances virus data accessibility with interactive SVG images and new resources for SARS-CoV-2, HIV, herpesviruses, and poxviruses. This update improves user access to crucial viral information and molecular biology data.
Area of Science:
- Virology
- Bioinformatics
- Molecular Biology
Background:
- ViralZone is a comprehensive knowledge repository for viruses.
- It integrates biological knowledge and databases, covering virion structure, genome, proteome, replication, and host-virus interactions.
Purpose of the Study:
- To enhance data accessibility and user experience on the ViralZone platform.
- To introduce new, virus-specific resources, particularly for coronaviruses (SARS-CoV-2), HIV, herpesviruses, and poxviruses.
Main Methods:
- Implementation of contextual popups for improved data retrieval.
- Integration of higher-resolution, dynamic, and interactive Scalable Vector Graphics (SVG) images.
- Development of a dedicated coronavirus-specific resource with regularly updated data.
Main Results:
- Enhanced data access through improved navigation and visualization tools.
- Introduction of interactive SVG images for dynamic exploration of viral data.
- Expansion of the database with specialized information on SARS-CoV-2 variants, HIV, herpesviruses, and poxviruses.
Conclusions:
- The updated ViralZone platform offers significantly improved access to diverse viral information.
- New interactive features and specialized resources enhance the utility of ViralZone for researchers and educators.
- The platform continues to be a valuable resource for studying viral biology and interactions.
Related Concept Videos
Viruses with RNA Genomes
35
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
35
Size and Structure of Viral Genomes
40
Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
40
Introduction to Virus
62
Viruses are unique biological entities that blur the boundary between living and non-living systems. Although they lack cellular structure and metabolic processes, they can exhibit characteristics of life when infecting a host. Their defining feature is a nucleic acid core, composed of either DNA or RNA, encapsulated within a protein coat called a capsid. This simple structure allows them to invade host cells and use their machinery for replication efficiently.Viral Structure and...
62


