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Updated: Jul 12, 2025

Dissolution Dynamic Nuclear Polarization Instrumentation for Real-time Enzymatic Reaction Rate Measurements by NMR
Published on: February 23, 2016
Optimal Sensing Protocol for Statistically Polarized Nano-NMR with NV Centers
Nicolas Staudenmaier1, Anjusha Vijayakumar-Sreeja1, Genko Genov1
1Institute for Quantum Optics, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
Abstract:
Diffusion noise represents a major constraint to successful liquid state nano-NMR spectroscopy. Using the Fisher information as a faithful measure, we theoretically calculate and experimentally show that phase sensitive protocols are superior in most experimental scenarios, as they maximize information extraction from correlations in the sample. We derive the optimal experimental parameters for quantum heterodyne detection (Qdyne) and present the most accurate statistically polarized nano-NMR Qdyne detection experiments to date, leading the way to resolve chemical shifts and J couplings at the nanoscale.
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