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Intestinal malabsorption in cystic fibrosis.

D J Penny, C B Ingall, P Boulton

Archives of Disease in Childhood

|November 1, 1986

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Cystic fibrosis patients show increased intestinal absorption of sugars, suggesting a gut issue contributes to malabsorption. This study used lactulose and L-rhamnose to assess intestinal function in these patients.

Area of Science:

Gastroenterology
Pediatric Medicine
Biochemistry

Background:

Cystic fibrosis is a genetic disorder affecting multiple organs, including the intestines.
Malabsorption is a common complication in cystic fibrosis patients.
The exact mechanisms of intestinal malabsorption in cystic fibrosis require further elucidation.

Purpose of the Study:

To investigate the hypothesis of an intestinal component in cystic fibrosis-related malabsorption.
To assess the intestinal absorption of specific non-metabolized sugars in cystic fibrosis patients.

Main Methods:

Six patients with cystic fibrosis were orally administered a solution containing lactulose and L-rhamnose.
Intestinal absorption was evaluated by measuring the urinary excretion of both sugars.

Related Experiment Videos

The ratio of lactulose to L-rhamnose urinary excretion was calculated.

Main Results:

The lactulose to L-rhamnose urinary excretion ratio was found to be elevated in cystic fibrosis patients.
This finding indicates altered intestinal permeability or absorption.

Conclusions:

The results support the hypothesis that intestinal malabsorption is a component of cystic fibrosis.
Further research into gut-specific therapies for cystic fibrosis may be warranted.