Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Arteries of the Lower Limbs01:24

Arteries of the Lower Limbs

194
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
194

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Postmortem MRI reveals distinct structural features in sudden unexpected death in epilepsy.

Epilepsia open·2026
Same author

The heartbeat evoked potential and the prediction of functional seizure semiology.

Brain communications·2026
Same author

Bilateral ictal eye closure in focal epileptic seizures: SEEG retrospective observational assessment from a tertiary epilepsy center.

Epileptic disorders : international epilepsy journal with videotape·2026
Same author

Dual mechanism of anti-seizure medications in controlling seizure activity.

Brain communications·2026
Same author

White matter resection and verbal memory deficits after temporal lobe epilepsy surgery.

Brain communications·2026
Same author

Association of Interictal Respiratory Variability and Severity of Postictal Hypoxemia After Generalized Convulsive Seizures.

Neurology·2026
Same journal

Effects of exercise and exercise timing on energy intake and appetite control: a randomised crossover trial in people with overweight or obesity with and without type 2 diabetes.

EBioMedicine·2026
Same journal

Immunogenicity and protective efficacy on non-adjuvanted CD40-targeting SARS-CoV-2 vaccines in non-human primates.

EBioMedicine·2026
Same journal

The role of mucosal IgA in protection against influenza A H1N1 virus infection in a real-world setting.

EBioMedicine·2026
Same journal

Early-life gut microbiome composition and rotavirus vaccine-induced IgA responses in U.S. infants: a longitudinal cohort study.

EBioMedicine·2026
Same journal

Endogenous neuroprotection in vascular cognitive impairment and dementia.

EBioMedicine·2026
Same journal

Trio analysis in dystonia identifies de novo KLC1 variants in a kinesinopathy with distinct motor and neurodevelopmental features.

EBioMedicine·2026
See all related articles

Related Experiment Video

Updated: Jul 12, 2025

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

2.7K

Complementary structural and functional abnormalities to localise epileptogenic tissue.

Jonathan J Horsley1, Rhys H Thomas2, Fahmida A Chowdhury3

  • 1CNNP Lab (www.cnnp-lab.com), Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle upon Tyne, United Kingdom.

Ebiomedicine
|October 28, 2023
PubMed
Summary
This summary is machine-generated.

Combining diffusion-weighted MRI (dMRI) and intracranial EEG (iEEG) data improves the localization of the epileptogenic zone in epilepsy surgery patients. This approach enhances seizure freedom rates by identifying and resecting maximal abnormalities.

Keywords:
Diffusion-weighted MRIEpilepsyIntracranial EEGMachine learningMulti-modal analysisSurgical prediction

More Related Videos

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

11.2K
Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
09:00

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

12.3K

Related Experiment Videos

Last Updated: Jul 12, 2025

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

2.7K
A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

11.2K
Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
09:00

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

12.3K

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Epileptology

Background:

  • Drug-refractory focal epilepsy requires precise localization of the seizure onset zone for surgical intervention.
  • Intracranial EEG (iEEG) and diffusion-weighted MRI (dMRI) are used to map seizure activity and white matter tracts, respectively.
  • Identifying the epileptogenic zone (EZ) is crucial for successful epilepsy surgery.

Purpose of the Study:

  • To investigate if combining structural connectivity from dMRI with functional iEEG abnormalities can improve EZ localization.
  • To determine if resecting maximal abnormalities in both modalities concurrently enhances surgical outcomes.
  • To explore the utility of dMRI-derived connectivity in guiding iEEG electrode placement.

Main Methods:

  • Retrospective analysis of 43 epilepsy patients who underwent surgery after iEEG implantation.
  • Quantification of interictal iEEG functional and dMRI structural connectivity abnormalities against normative data.
  • Exploration of the relationship between resection of maximal abnormalities and seizure freedom (ILAE 1 or 2 at one year).

Main Results:

  • Seizure freedom at one year was achieved by 58% of patients.
  • Resection of maximal connectivity and iEEG abnormalities was associated with a 15-fold increase in seizure freedom (p=0.008).
  • A decision tree using both modalities correctly classified 84% of patients regarding surgical outcome.

Conclusions:

  • Both dMRI-derived structural connectivity and iEEG abnormalities can effectively localize epileptogenic tissue.
  • Integrating these two modalities provides complementary information for pre-surgical evaluations in epilepsy.
  • This combined approach holds potential for improving surgical outcomes in patients with drug-refractory focal epilepsy.