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Updated: Jul 12, 2025

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Injectable systems for long-lasting insulin therapy
Kumar Kulldeep Niloy1, Tao L Lowe2
1Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
New injectable insulin delivery systems offer longer glycemic control, potentially improving diabetes management and patient adherence beyond daily injections. These advancements aim for once-weekly insulin administration.
Area of Science:
- Endocrinology
- Biotechnology
- Pharmaceutics
Background:
- Insulin therapy is crucial for managing diabetes and hyperglycemia.
- Short insulin half-life (4-6 minutes) limits chronic treatment effectiveness.
- Current insulin analogues require frequent injections, leading to compliance issues.
Purpose of the Study:
- To review advancements in injectable insulin analogues and delivery systems.
- To cover the development pipeline from prototype to marketed products.
- To explore technologies enabling long-lasting insulin release for improved diabetes care.
Main Methods:
- Comprehensive review of scientific literature and clinical trial data.
- Analysis of various injectable delivery systems (microspheres, nanoparticles, etc.).
- Examination of insulin analogue development using recombinant DNA technology and protein engineering.
Main Results:
- Insulin analogues offer extended glycemic control (up to 42 hours).
- Injectable delivery systems are being developed for once-weekly insulin administration.
- Several long-acting insulin technologies have progressed to clinical trials and market.
Conclusions:
- Injectable delivery systems represent a significant advancement in diabetes treatment.
- Long-lasting insulin technologies aim to overcome limitations of frequent injections.
- These innovations hold promise for enhanced patient compliance and diabetes management.
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